Beilstein J. Nanotechnol.2014,5, 2293–2307, doi:10.3762/bjnano.5.238
complex that was used as an artificialenzyme against multi-drug-resistant cancer cells was confirmed. A complex of diethylaminoethyl–dextran–methacrylic acid methylester copolymer (DDMC)/paclitaxel (PTX), obtained with PTX as the guest and DDMC as the host, formed a nanoparticle 50–300 nm in size. This
the effectiveness of PTX alone (p < 0.036). Above all, the DDMC/PTX complex is not degraded in cells and acts as an intact supramolecular assembly, which adds a new species to the range of DDS.
Keywords: artificialenzyme; diethylaminoethyl–dextran–MMA; graft copolymer; multi-drug resistance of
selectivity. This complex should be regarded as an artificialenzyme with substrate specificity, and it is reported to exert an anticancer effect as an artificialenzyme.
Polymer micelle
Characteristics of the 2-diethylaminoethyl-dextran methyl methacrylate graft copolymer: DDMC is a copolymer that is formed
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Figure 1:
Non-viral vectoring of DEAE–dextran and DEAE–dextran–MMA graft copolymer (DDMC). (a) Transfection o...